Evaluating the association between the SHANK3 gene and bipolar disorder
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- 作者：Chen Zhang ; 1 ; zhangchen645@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Zhiguo Wu1 ; Wu Hong1 ; Daihui Peng1 ; Yiru Fang ; 1 ; yirufang@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; yirufang@shmc.org.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bipolar disorder ; SHANK3 ; RT-PCR ; SNP ; Association
- 刊名：Psychiatry Research
- 出版年：2016
- 出版时间：30 October 2016
- 年：2016
- 卷：244
- 期：Complete
- 页码：284-288
- 全文大小：434 K
文摘
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The first association study of SHANK3 gene with bipolar disorder (BD).
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Peripheral SHANK3 mRNA expression was examined in drug-naïve BD patients and healthy controls.
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While no significant association was observed in Han Chinese, rs9616915 might be marginally associated with BD in Europeans.
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SNP rs9616915 has a functional effect on the SHANK3 mRNA expression in the hippocampus.