- 作者：Xu Zhang ; Chen Zhang ; Zhiguo Wu ; Zuowei Wang ; Daihui Peng ; Jun Chen ; Wu Hong ; Chengmei Yuan ; Zezhi Li ; Shunying Yu ; Yiru Fang
- 关键词：Major depressive disorder ; Bipolar disorder ; CACNA1C ; Polymorphism ; Age at onset
- 刊名：Journal of Affective Disorders
- 出版年：2013
- 出版时间：5 September, 2013
- 年：2013
- 卷：150
- 期：2
- 页码：261-265
- 全文大小：394 K
Background
A growing body of evidence highlights the existence of shared genetic susceptibility to both major depressive disorder (MDD) and bipolar disorder (BD), suggesting some potential genetic overlap between the disorders. Genome-wide association studies have identified consistent association of single nucleotide polymorphisms of the ¦Á-1 C subunit of the L-type voltage-gated calcium channel gene (CACNA1C) with MDD and BD, suggesting CACNA1C as a promising candidate gene for susceptibility to mood disorders. In the present study, we tested the association of CACNA1C with MDD and BD in Han Chinese.Methods
We genotyped three potentially functional polymorphisms in 635 MDD patients, 286 BD patients and 730 normal, control patients.
Results
The genotype frequencies of SNP rs1051375 showed statistically significant differences between the BD and control groups (P=0.005). At the allele level, the difference of G allele frequency of rs1051375 between BD patients and control subjects was also significant (P=0.011; OR=1.30, 95 % CI: 1.06-1.58). We found that GG genotype of rs1051375 carriers had a lower age at onset than those with the AG or AA genotype, and the mean¡Àstandard deviation ages at onset of GG, AG and AA carriers were 24.04¡À4.22, 25.76¡À4.75 and 25.78¡À4.33 years, respectively. Neither genotype nor allele frequencies of the three polymorphisms were found to be significantly different between the MDD patients and control subjects.
Limitations
The relative small sample size in BD group should be considered a limitation of this study.
Conclusions
Our initial findings support a potential association of CACNA1C as a genetic risk factor for BD susceptibility.