GNAQ and GNA11 mutations occur in 9.5% of mucosal melanoma and are associated with poor prognosis
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- 作者：Xinan Sheng1 ; Yan Kong1 ; Yiqian Li ; Qiannan Zhang ; Lu Si ; Chuanliang Cui ; Zhihong Chi ; Bixia Tang ; Lili Mao ; Bin Lian ; Xuan Wang ; Xieqiao Yan ; Siming Li ; Jie Dai ; Jun Guo ; guoj307@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mucosal melanoma ; GNAQ ; GNA11 ; Mutation ; Overall survival ; Targeted therapy
- 刊名：European Journal of Cancer
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：156-163
- 全文大小：462 K
文摘
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We examine somatic mutations of GNAQ and GNA11 in 284 cases of mucosal melanomas.
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GNAQ and GNA11 mutations occur frequently in mucosal melanomas.
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GNAQ and GNA11 mutations are associated with a poor prognosis of mucosal melanomas.