Early exercise training improves ischemic outcome in rats by cerebral hemodynamics

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• 作者：Shan Tian ; Youcan Zhang ; Song Tian ; Xiaojiao Yang ; Kewei Yu ; Yuling Zhang ; Xiafeng Shen ; Liping Zhang ; Yu Sun ; Hongyu Xie ; Zhijie He ; Zhenzhen Guo ; Jie Jia ; Yi Wu ; Yulong Bai ; Yulian Zhu ; Yong Cheng ; Xinggang Wang ; Junfa Wu ; Nianhong Wang ; et al.
• 关键词：Ischemic stroke ; Very early initiated physical rehabilitation ; Cerebral blood flow ; Brain microvascular endothelial cells ; Apoptosis
• 刊名：Brain Research
• 出版年：2013
• 出版时间：2 October, 2013
• 年：2013
• 卷：1533
• 期：Complete
• 页码：114-121
• 全文大小：6240 K

文摘

This study examined whether very early initiated physical rehabilitation (VEIPR), as a recommended therapy for postischemia, could improve motor performance and cerebral blood flow (CBF). Adult male rats with ischemic injury caused by middle cerebral artery occlusion (MCAO) were trained to run on a treadmill for 30 min per day at 12 m/min. Through such exercise training for 3 days, the ischemic rats exhibited increased motor function and decreased infarct volume, as measured by a behavioral score and 2,3,5-triphenyltetrazolium chloride (TTC) staining method, as well as accelerated CBF, as detected with laser speckle imaging (LSI). Furthermore, to determine whether the observed improved CBF provided the protective factor for motor function recovery, we investigated the apoptosis of ischemic rat brain microvascular endothelial cells (rBMECs), which accepted the mechanical force of CBF directly, under flow intervention. The findings indicated that a modest flow decreased cell apoptosis in the ischemic condition and that this effect is magnitude dependent, as excessive flow increased apoptosis.