Enzymatic synthesis of human blood group P1 pentasaccharide antigen

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• 作者：Dawa Tsering^a ; ¹ ; Congcong Chen^a ; ¹ ; Jinfeng Ye^a ; Zhipeng Han^a ; Bai-qian Jing^b ; ^{qiludrug@163.com} ; Xian-wei Liu^a ; Xi Chen^c ; Fengshan Wang^a ; ^d ; Peixue Ling^a ; ^e ; Hongzhi Cao^a ; ^f ; ^{hzcao@sdu.edu.cn}
• 关键词：P1 antigen ; Human blood group ; Glycosylation ; One-pot multienzyme ; Glycosyltransferase
• 刊名：Carbohydrate Research
• 出版年：2017
• 出版时间：13 January 2017
• 年：2017
• 卷：438
• 期：Complete
• 页码：39-43
• 全文大小：466 K
• 卷排序：438

文摘

Highly efficient enzymatic synthesis of human P1PK blood group P1 pentasaccharide antigen. Three steps with an overall yield of 46% from 3 simple starting materials. One-pot multienzyme sequential glycosylation with in situ generation of sugar nucleotide donors.