The Transcription Factor GATA3 Is Critical for the Development of All IL-7R伪-Expressing Innate Lymphoid Cells

详细信息    查看全文

• 作者：Ryoji Yagi¹ ; ⁵ ; ⁶ ; Chao Zhong¹ ; ⁵ ; Daniel L. Northrup² ; ⁵ ; Fang Yu¹ ; Nicolas Bouladoux³ ; Sean Spencer³ ; Gangqing Hu² ; Luke Barron³ ; Suveena Sharma¹ ; Toshinori Nakayama⁴ ; Yasmine Belkaid³ ; Keji Zhao² ; Jinfang Zhu¹ ; ^{jfzhu@niaid.nih.gov" class="auth_mail}
• 刊名：Immunity
• 出版年：20 March, 2014
• 年：2014
• 卷：40
• 期：3
• 页码：378-388
• 全文大小：1347 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferences

Summary

Innate lymphoid cells (ILCs) are critical in innate immune responses to pathogens and lymphoid organ development. Similar to CD4⁺ T helper (Th) cell subsets, ILC subsets positive for interleukin-7 receptor 伪 (IL-7R伪) produce distinct sets of effector cytokines. However, the molecular control of IL-7R伪⁺ ILC development and maintenance is unclear. Here, we report that GATA3 was indispensable for the development of all IL-7R伪⁺ ILC subsets and T聽cells but was not required for the development of classical natural killer cells. Conditionally Gata3-deficient mice had no lymph nodes and were susceptible to Citrobactor rodentium infection. After the ILCs had fully developed, GATA3 remained important for the maintenance and functions of ILC2s. Genome-wide gene expression analyses indicated that GATA3 regulated a similar set of cytokines and receptors in Th2 cells and ILC2s, but not in ILC3s. Thus, GATA3 plays parallel roles in regulating the development and functions of CD4⁺ T聽cells and IL-7R伪⁺ ILCs.