Morphology and cell responses of three-dimensional porous silica nanofibrous scaffold prepared by sacrificial template method

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• 作者：Honglin Luo^a ; ^b ; Zhongyuan Zhou^a ; Gen Li^a ; Wei Li^a ; Zhiqing Li^c ; Guangyao Xiong^a ; ^{xiongguangyao@163.com} ; Yong Zhu^d ; Fanglian Yao^d ; Ruisong Guo^b ; Yizao Wan^a ; ^b ; ^{yzwantju@126.com}
• 关键词：Silica ; Nanofiber ; Scaffold ; Biomedical applications
• 刊名：Journal of Non-Crystalline Solids
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：457
• 期：Complete
• 页码：145-151
• 全文大小：1307 K
• 卷排序：457

文摘

Three-dimensional (3D) nanofibrous scaffolds morphologically mimicking natural extracellular matrix show great potential in the application of tissue repair. Herein, we report a novel 3D nanofibrous silica (SiO2) scaffold fabricated via a sacrificial template method. The sacrificed template used was 3D bacterial cellulose and the resultant silica nanofiber has a ultrasmall diameter of 21 nm. SEM, TEM, and AFM evidence the 3D porous nanofibrous structure and pore structure measurement confirms the existence of macro- and meso-pores in the as-prepared silica scaffold. Cell studies using osteoblast cells demonstrate excellent biocompatibility and high ALP activity. These results suggest that the 3D silica nanofibrous scaffold is a promising candidate for hard tissue engineering.