Fabrication of two-layer nanotubes with the pear-like structure by an in-situ voltage up anodization and the application as a drug delivery platform

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• 作者：Lihong Shi¹ ; Hong Xu¹ ; Xiaoming Liao ; ^{sherman_xm@163.com" class="auth_mail" title="E-mail the corresponding author} ; Guangfu Yin ; Yadong Yao ; Zhongbing Huang ; Xianchun Chen ; Ximin Pu
• 关键词：Two-layer TiO2 nanotubes ; In-situ anodization ; Pear-like structure ; Drug release
• 刊名：Journal of Alloys and Compounds
• 出版年：2015
• 出版时间：25 October 2015
• 年：2015
• 卷：647
• 期：Complete
• 页码：590-595
• 全文大小：1671 K

文摘

Because of extensive applications, self-assembled anodic titania nanotube (TNT) arrays are drawing increasing interest. In our work, two-layer TNT with pear-like structure was successfully obtained by in-situ voltage up anodization process. The growth mechanism of the second-layer tube are discussed. And the loading capacity and releasing property of two-layer nanotubes were investigated. It is demonstrated that different interface structures may grow through different second stage anodization voltage. And the higher bovine serum albumin loading of 76.86 渭g/cm² is obtained for the two-layer TNTs. Compared with the single layer TNTs, two-layer TNTs display slower release rate with 29% of the protein release in the first 10 min, and the sustained release time is extended to 180 min, 1.5 times that of the single layer TNTs. These advanced nanotube array thin films may exhibit a promising application in the localized drug-delivery platform with its controllable releasing characteristic for medical implants.