Suppression of outward K+ currents by activating dopamine D1 receptors in rat retinal ganglion cells through PKA and CaMKII signaling pathways
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- 作者：Qian Lia ; c ; d ; f ; 14110700008@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Na Wua ; b ; d ; e ; f ; tgf_b@sina.cn" class="auth_mail" title="E-mail the corresponding author ; Peng Cuia ; c ; d ; f ; 14111520017@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Feng Gaoa ; b ; d ; e ; f ; fenggao@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Wen-Jing Qiana ; c ; d ; f ; 15111520021@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yanying Miaoa ; c ; d ; f ; yymiao@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xing-Huai Suna ; b ; d ; e ; f ; xhsun@shmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zhongfeng Wanga ; b ; c ; d ; e ; f ; zfwang@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：4-AP ; 4-aminopyridine ; AC ; adenylate cyclase ; Bis IV ; bisindolylmaleimide IV ; BKCa ; large-conductance Ca2+-activated K+ channels ; CaMKII ; calcium/calmodulin-dependent protein kinase II ; CNS ; central nervous system ; DA ; dopamine ; DMSO ; dimethyl sulfoxide ; EGTA ; ethylene glycol-bis(β-aminoethyl ether) N ; N ; N&rsquo ; N&rsquo ; -tetraacetic acid ; ERK ; extracellular signal-regulated kinase ; Gb ; glybenclamide ; HEPES ; 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid ; Ih ; hyperpolarization-activated ca
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：1635
- 期：Complete
- 页码：95-104
- 全文大小：1448 K
文摘
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Activation of dopamine D1 receptors suppresses outward K+ current in rat RGCs.
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SKF81297 mainly suppresses the Gb- and 4-AP-sensitive current components.
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The SKF81297 effect is mediated by cAMP/PKA and CaMKII signaling pathways.
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PKC and MAPK/ERK signaling pathways are not involved in the SKF81297 effect.