Dysfunctional co-expression network analysis of familial hypercholesterolemia

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• 作者：Yizhou Ye ; Kefei Li ; Jian Liu ; Mingqiu Li ; Wei Wang ; Ruxing Wang ; Jian Zou ; Ping Xie ; Liuyan Wei ; Guoqing Jiao ; Zhongxiang Yuan
• 关键词：Co-expression network ; Differentially expressed genes ; Familial hypercholesterolemia
• 刊名：Journal of Cardiology
• 出版年：2013
• 出版时间：July, 2013
• 年：2013
• 卷：62
• 期：1
• 页码：58-62
• 全文大小：1848 K

文摘

Familial hypercholesterolemia (FH) is an inherited disorder of blood lipid metabolism characterized by high serum low-density lipoprotein cholesterol levels and premature coronary artery disease. In this study, we used a system biology approach to identify co-expressed gene pairs that were potentially involved in the progression of FH and constructed a conserved co-expression network using these genes. A total of 4232 co-expressed relationships were identified and we verified the significance by random permutation. FH patients showed differences in lipoprotein and cholesterol metabolism in circulating monocytes and lymphocytes compared to healthy controls. We hope our study could aid in understanding of FH and could provide the basis for FH biomarker identification.