Neuroprotective effects of miR-27a against traumatic brain injury via suppressing FoxO3a-mediated neuronal autophagy

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• 作者：Liqian Sun^a ; Manman Zhao^b ; Yan Wang^b ; Aihua Liu^a ; Ming Lv^a ; Youxiang Li^a ; Xinjian Yang^a ; Zhongxue Wu^a ; ^{zhongxuewu@yeah.net}
• 关键词：MicroRNA-27a ; Traumatic brain injury ; FoxO3a ; Autophagy ; Hippocampus
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1141-1147
• 全文大小：1885 K
• 卷排序：482

文摘

Enhanced FoxO3a expression is associated with decreased miR-29b level after TBI. Overexpression of miR-27 attenuates neurological deficits and brain injury post-TBI. Overexpression miR-27a suppresses TBI-induced neuronal autophagy. The suppression of FoxO3a by miR-27a is mediated by putative sites at their 3′-UTRs. Knockdown of FoxO3a blocks neuronal autophagy after TBI.