Granulocyte colony-stimulating factor decreases the Th1/Th2 ratio in peripheral blood mononuclear cells from patients with chronic immune thrombocytopenic purpura in vitro

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• 作者：Fei Ge^a ; Zhuo Zhang^a ; ^b ; Jinxiao Hou^a ; Fenglin Cao^b ; Yingmei Zhang^b ; Ping Wang^a ; ^c ; Hong Wei^a ; Jin Zhou^a ; ^b ; ^{jinzhou1111@126.com}
• 关键词：Granulocyte colony-stimulating factor ; Chronic immune thrombocytopenia purpura ; Th1/Th2 ; Granulocyte colony-stimulating factor receptor ; T-box expressed in T cells ; GATA-binding protein 3
• 刊名：Thrombosis Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：148
• 期：Complete
• 页码：76-84
• 全文大小：1005 K
• 卷排序：148

文摘

Our findings suggest the therapeutic potential of G-CSF in patients with ITP. It elucidates the immunomodulatory mechanisms of G-CSF in Th1/Th2 cells in vitro. G-CSF decreased the Th1/Th2 ratio in PBMCs from patients with ITP in vitro. G-CSF decreased T-bet/GATA-3 mRNA ratio in PBMCs from patients with ITP in vitro. The study shows that Th1 and Th2 cells could express G-CSFR.