Design, synthesis and biological evaluation of dihydroquinoxalinone derivatives as BRD4 inhibitors
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- 作者：Yifei Yanga ; Leilei Zhaob ; Bin Xub ; LingYun Yangb ; Jian Zhangb ; Huibin Zhangb ; Jinpei Zhoua ; jpzhou668@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：BRD4 inhibitors ; Cancer ; Molecular docking ; Dihydroquinoxalinone derivatives
- 刊名：Bioorganic Chemistry
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：68
- 期：Complete
- 页码：236-244
- 全文大小：1299 K
文摘
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Novel dihydroquinoxalinone BRD4 inhibitors were designed and synthesized.
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Molecular docking was performed.
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Binding activity in BRD4 was determined by AlphaScreen assay.
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Cell viability assay was evaluated in the MV-4-11 cell line.