Cannabinoid receptor-2 stimulation suppresses neuroinflammation by regulating microglial M1/M2 polarization through the cAMP/PKA pathway in an experimental GMH rat model
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- 作者：Yihao Taoa ; Lin Lib ; Bing Jianga ; Zhou Fenga ; Liming Yanga ; Jun Tanga ; Qianwei Chena ; Jianbo Zhanga ; Qiang Tana ; Hua Fenga ; Zhi Chena ; zhichen@tmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Gang Zhua ; gangzhu6666@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cannabinoid receptor-2 ; Microglial polarization ; PKA ; Anti-inflammation
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：58
- 期：Complete
- 页码：118-129
- 全文大小：3085 K
文摘
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GMH-induced microglia M1 polarization enhances the neuroinflammation.
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JWH133 alleviates GMH-induced neuroinflammation by promoting M1 to M2 conversion.
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JWH133 regulates microglia M1/M2 polarization in microglia cell cultures.
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JWH133 enhances microglia M2 polarization through cAMP/PKA pathway.