Glucagon-like peptide-1 inhibits the receptor for advanced glycation endproducts to prevent podocyte apoptosis induced by advanced oxidative protein products
刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:22 January 2017
年:2017
卷:482
期:4
页码:1413-1419
全文大小:856 K
卷排序:482
文摘
GLP-1 partially antagonizes AOPP-induced apoptosis in podocytes. The mechanism might be associated with interfering with the AOPP-RAGE axis. GLP-1 decreases oxidative stress and inhibits the downstream p53/Bax/caspase-3 apoptotic pathway.