Coupling hybridization chain reaction with catalytic hairpin assembly enables non-enzymatic and sensitive fluorescent detection of microRNA cancer biomarkers
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- 作者：Yulian Wei ; Wenjiao Zhou ; Xin Li ; Yaqin Chai ; Ruo Yuan ; Yun Xiang ; yunatswu@swu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hybridization chain reaction ; Catalytic hairpin assembly ; MicroRNA ; Fluorescence ; Signal amplification
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：77
- 期：Complete
- 页码：416-420
- 全文大小：1013 K
文摘
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The integration of HCR with CHA leads to remarkable signal amplification.
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Enzyme-free and dual amplified detection of the microRNA-141 biomarker is achieved.
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The developed sensor can discriminate microRNA-141 from its family members.