Toxicology of 3-epi-deoxynivalenol, a deoxynivalenol-transformation product by Devosia mutans 17-2-E-8
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- 作者：Jian Wei He<sup>asup><sup> ; sup><sup>bsup> ; Genevieve S. Bondy<sup>csup><sup> ; sup><sup>genevieve.bondy@hc-sc.gc.ca" class="auth_mail" title="E-mail the corresponding authorsup> ; Ting Zhou<sup>asup><sup> ; sup><sup>Ting.Zhou@agr.gc.ca" class="auth_mail" title="E-mail the corresponding authorsup> ; Don Caldwell<sup>csup> ; Greg J. Boland<sup>bsup> ; Peter M. Scott<sup>csup>
- 关键词：Deoxynivalenol ; Vomitoxin ; DON ; 3-epi-DON ; Cytotoxicity ; BrdU bioassay ; 3T3 fibroblasts cell line ; MTT bioassay ; Caco-2 cell line ; B6C3F1 mouse
- 刊名：Food and Chemical Toxicology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：84
- 期：Complete
- 页码：250-259
- 全文大小：1524 K
文摘
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The IC<sub>50sub> value of 3-epi-DON was 357 times higher than DON in a MTT bioassay.
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The IC<sub>50sub> value of 3-epi-DON was 1181 times higher than that of DON in a BrdU assay.
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3-epi-DON was at least 50 times less toxic than DON in B6C3F<sub>1sub> mice.