Examining the relationship between lifetime stressful life events and the onset of major depression in Chinese women

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• 作者：Ming Tao^a ; Yihan Li^b ; Dong Xie^b ; Zhiyang Wang^c ; Jianying Qiu^d ; Wenyuan Wu^e ; Jing Sun^f ; Zhoubing Wang^g ; Danhong Tao^a ; Hongsu Zhao^h ; Tian Tianⁱ ; Jingxuan Zhang^j ; Chengge Gao^k ; Qihui Niu^l ; Qiang Li^m ; Shanming Liuⁿ ; Jia Liu^o ; Yunshu Zhang^p ; Qiang He^q ; Han Rong^r ; Zhaoyu Gan^s ; Jianying Li^t ; Xiansheng Chen^u ; Jiyang Pan^v ; Yi Li^w ; Yanping Cui^x ; Wei Han^y ; Huan Ma^z ; Shoufu Xie^aa ; Guixing Jin^ab ; Ling Li^ac ; Ruiling Zhang^ad ; Qingrong Tan^ae ; Jun Zhang^af ; Jing Guan^ag ; Shenxun Shi^c ;   ; ^d ; Yiping Chen^ah ; Kenneth S. Kendler^ai ; Jonathan Flint^b ; Jingfang Gao^h ;   ; ^{gjingfang@hotmail.com}
• 关键词：Major depressive disorder ; Stressful life event ; Social adversity ; Symptom
• 刊名：Journal of Affective Disorders
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：135
• 期：1-3
• 页码：95-99
• 全文大小：180 K

文摘

Background

In European and US studies, patients with major depressive disorder (MDD) report more stressful life events (SLEs) than controls, but this relationship has rarely been studied in Chinese populations.

Methods

Sixteen lifetime SLEs were assessed at interview in two groups of Han Chinese women: 1970 clinically ascertained with recurrent MDD and 2597 matched controls. Diagnostic and other risk factor information was assessed at personal interview. Odds ratios (ORs) were calculated by logistic regression.

Results

60 % of controls and 72 % of cases reported at least one lifetime SLE. Fourteen of the sixteen SLEs occurred significantly more frequently in those with MDD (median odds ratio of 1.6). The three SLEs most strongly associated with risk for MDD (OR > 3.0) preceded the onset of MDD the majority of the time: rape (82 % ), physical abuse (100 % ) and serious neglect (99 % ).

Limitations

Our results may apply to females only. SLEs were rated retrospectively and are subject to biases in recollection. We did not assess contextual information for each life event.

Conclusions

More severe SLEs are more strongly associated with MDD. These results support the involvement of psychosocial adversity in the etiology of MDD in China.