Elevated MD-1 mRNA is found in the colon of IBD patients and diseased mice.
MD-1−/− mice are protected against DSS-induced colitis characterized by decreased colonic inflammatory gene expression and infiltration of colonic inflammatory cells.
MD-1−/− mice do not alter intestinal permeability after DSS treatment.
MD-1 deficiency modulates the function of colonic lamina propria DCs (LPDCs).