Quercetin stabilizes apolipoprotein E and reduces brain Aβ levels in amyloid model mice
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- 作者：Xilin Zhang1 ; Jin Hu1 ; Li Zhong ; Na Wang ; Longyu Yang ; Chia-Chen Liu ; Huifang Li ; Xin Wang ; Ying Zhou ; Yunwu Zhang ; Huaxi Xu ; Guojun Bu ; Bu.Guojun@mayo.edu" class="auth_mail" title="E-mail the corresponding author ; Jiangxing Zhuang ; jiangxingzhuang@xmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Quercetin ; AD ; ApoE ; Aβ
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：108
- 期：Complete
- 页码：179-192
- 全文大小：2532 K
文摘
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Quercetin can significantly increase apoE levels by inhibiting apoE degradation in astrocytes.
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Quercetin can reduce AD-related pathology by stabilizing apoE upon secretion.
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By modulating the level or stability of the apoE protein creates new therapeutic opportunities for AD treatment.