Pd(II)-catalyzed intramolecular aminopalladation/direct C-H arylation under aerobic conditions: synthesis of pyrrolo[1,2-a]indoles

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• 作者：Tiffany Piou^a ; ^b ; Luc Neuville^b ; ^{luc.neuville@icsn.cnrs-gif.fr} ; Jieping Zhu^a ; ^b ; ^{jieping.zhu@epfl.ch}
• 关键词：Palladium catalysis ; Domino reaction ; C&ndash ; H activation ; Indole ; Aminopalladation
• 刊名：Tetrahedron
• 出版年：2013
• 出版时间：3 June, 2013
• 年：2013
• 卷：69
• 期：22
• 页码：4415-4420
• 全文大小：773 K

文摘

Heating a DMA/pivalic acid (v/v=4/1) solution of diversely substituted 6-(phenylamino)hex-2-ynoates in the presence of a catalytic amount of Pd(OAc)₂ under oxygen atmosphere afforded pyrrolo[1,2-a]indoles in moderate to good yields. A domino sequence involving intramolecular aminopalladation followed by C-H activation and reductive elimination was proposed to account for the observed bis-cyclization.