Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism
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- 作者：Thomas C. Fung1 ; 2 ; 3 ; 4 ; Nicholas J. Bessman2 ; 3 ; 4 ; Matthew R. Hepworth2 ; 3 ; 4 ; Nitin Kumar5 ; Naoko Shibata6 ; 7 ; Dmytro Kobuley1 ; Kelvin Wang1 ; Carly G.K. Ziegler8 ; Jeremy Goc2 ; 3 ; 4 ; Tatsuichiro Shima9 ; Yoshinori Umesaki9 ; R. Balfour Sartor10 ; Kaede V. Sullivan11 ; Trevor D. Lawley5 ; Jun Kunisawa12 ; Hiroshi Kiyono6 ; 7 ; Gregory F. Sonnenberg2 ; 3 ; 4 ; gfsonnenberg@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：44
- 期：3
- 页码：634-646
- 全文大小：4334 K
文摘
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Lymphoid-resident commensal bacteria (LRCs) colonize intestinal lymphoid tissues
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LRCs promote tissue-specific Th17 cell and ILC3 responses in intestinal tissues
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IL-22 enhances LRC colonization of intestinal lymphoid tissues
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LRCs provide host tissue protection during DSS in an IL-10R-dependent manner