Activated AMPK boosts the Nrf2/HO-1 signaling axis鈥擜 role for the unfolded protein response
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- 作者：Kristin Zimmermann ; Johannes Baldinger ; Barbara Mayerhofer ; Atanas G. Atanasov ; Verena M. Dirsch ; Elke H. Heiss ; elke.heiss@univie.ac.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACC ; acetyl-CoA carboxylase ; AMPK ; AMP-activated kinase ; ARE ; antioxidant response element ; 尾TrcP1 ; 尾-transducin-repeat containing protein 1 ; CaMKK ; calcium calmodulin-dependent kinase kinase ; CHO ; Chinese hamster ovary ; DCF ; dichlorofluorescein ; DMSO ; dimethyl sulfoxide ; ER ; endoplasmic reticulum ; FCS ; fetal calf serum ; GSH ; glutathione (reduced) ; GSK3尾 ; glycogen synthase kinase 3尾 ; GSSG ; oxidized glutathione ; HO-1 ; heme oxygenase 1 ; Hrd1 ; synoviolin/Hrd1 (HMG-CoA reductase degradation)-ubiquit
- 刊名：Free Radical Biology and Medicine
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：88
- 期：part_PB
- 页码：417-426
- 全文大小：869 K
文摘
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Activated AMPK boosts the Nrf2/HO鈥? signaling axis in xanthohumol鈥恡reated cells.
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Xanthohumol leads to AMPK activation in an LKB1鈥恉ependent manner.
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The AMPK boost hits on a step prior to or at transcription of HO鈥? mRNA.
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Inhibition of GSK3尾 or mTOR is not involved in the observed AMPK boost.
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Higher ER stress accounts for the lower Nrf2/HO1 response in AMPK鈥恉eficient cells.