Influence of the graft density of hydrophobic groups on thermo-responsive nanoparticles for anti-cancer drugs delivery
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- 作者：Fangqin Wang ; Guixue Xia ; Xuqian Lang ; Xuanxuan Wang ; Zixian Bao ; Zeenat Shah ; Xiaojie Cheng ; Ming Kong ; Chao Feng ; Ya Liu ; yaliu@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xiguang Chen ; xgchen@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hydrophobic group ; Thermo-responsive ; Nanoparticles ; Graft density ; Drug delivery
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：148
- 期：Complete
- 页码：147-156
- 全文大小：2478 K
文摘
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LCST of various DAHBC could be adjusted from 35.4 °C to 42.1 °C.
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Lower DS of DOCA lead to Higher LCST.
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The DAHBC NPs had high antitumor drugs encapsulation efficiency.
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The DAHBC NPs displayed thermal-responsive drug release profiles.
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CUR-loaded DAHBC NPs significantly inhibited cells growth at 43 °C (>LCST).