Tet3-Mediated DNA Demethylation Contributes to the Direct Conversion of Fibroblast to Functional Neuron

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• 作者：Juan Zhang¹ ; ⁴ ; Shuangquan Chen¹ ; ² ; ³ ; ⁴ ; Dongming Zhang¹ ; ² ; ³ ; Zixiao Shi¹ ; Hong Li¹ ; Tongbiao Zhao¹ ; Baoyang Hu¹ ; Qi Zhou¹ ; Jianwei Jiao¹ ; ⁵ ; ^{jwjiao@ioz.ac.cn}
• 关键词：trans-differentiation ; fibroblast ; neuron ; iN cell ; conversion ; induction ; Tet3 ; DNA demethylation
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：22 November 2016
• 年：2016
• 卷：17
• 期：9
• 页码：2326-2339
• 全文大小：6372 K
• 卷排序：17

文摘

Tet3 rapidly and efficiently promotes the direct conversion of fibroblasts into neurons Tet3-mediated demethylation leads to transcriptional changes activating neuronal genes Tet3-induced neurons display maturing firing patterns and form functional synapses