In vitro antibacterial activity of tigecycline in comparison with doxycycline, ciprofloxacin and rifampicin against Brucella spp.
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- 作者：Hale Turan ; H ; e Arslan ; Ö ; zlem Kurt Azap ; Kı ; vanç ; Ş ; erefhanoğ ; lu ; Hikmet Uncu
- 关键词：Fluoroquinolone ; Resistance ; parC ; gyrA ; Streptococcus pyogenes
- 刊名：International Journal of Antimicrobial Agents
- 出版年：2007
- 出版时间：August 2007
- 年：2007
- 卷：30
- 期：2
- 页码：186-187
- 全文大小：84 K
文摘
The resistance mechanisms and clonal relationship were determined for two Streptococcus pyogenes isolates with high-level resistance to levofloxacin as well as to other fluoroquinolones. DNA amplification and sequencing revealed a serine-81→phenylalanine substitution in GyrA and a double substitution in ParC of serine-79→phenylalanine and aspartic acid-91→asparagine. Pulsed-field gel electrophoresis analysis and emm typing determined that both isolates were emm type 28 and were genetically indistinguishable.