Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression
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- 作者：Ré ; my Denzler1 ; Sean E. McGeary2 ; 3 ; 4 ; Alexandra C. Title1 ; Vikram Agarwal2 ; 3 ; 4 ; 5 ; David P. Bartel2 ; 3 ; 4 ; dbartel@wi.mit.edu" class="auth_mail" title="E-mail the corresponding author ; Markus Stoffel1 ; 6 ; stoffel@biol.ethz.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：competing endogenous RNA ; miRNA ; target abundance ; cooperatively ; gene regulation ; base pair complementarity ; miRNA degradation
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：3 November 2016
- 年：2016
- 卷：64
- 期：3
- 页码：565-579
- 全文大小：3022 K
文摘
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ceRNA-mediated derepression is typically insensitive to reduced miRNA activity
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Extensively paired sites can reduce derepression thresholds by triggering miRNA decay
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Weak sites can contribute to target-site competition without imparting repression
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Closely spaced sites of the same or different miRNAs cooperatively sequester miRNAs