Effects of alprazolam and cannabinoid-related compounds in an animal model of panic attack
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- 作者：Luara A. Batista<sup>asup> ; Andrea S. Haibara<sup>bsup> ; Luiz C. Schenberg<sup>csup> ; Fabricio A. Moreira<sup>dsup><sup> ; sup><sup>fabriciomoreira@icb.ufmg.br" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Panic ; Aversion ; Chemoreflex ; Cannabinoid ; CB1 receptor ; Benzodiazepines
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：508-514
- 全文大小：460 K
文摘
- ss="listitem" id="list_lis0005">
- ss="label">•
r0005">The pharmacological treatment of panic disorder is limited.
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r0010">One of the few animal models of panic is the response to KCN injection in rats.
- ss="label">•
r0015">The KCN model is useful for screening new potential treatments for panic disorder.
- ss="label">•
r0020">Cannabinoid compounds, which may alleviate anxiety, failed to inhibit KCN effects.
- ss="label">•
r0025">Alprazolam, a benzodiazepine, abolished KCN behavioral and cardiovascular effects.