Novel therapeutic intervention for osteoporosis prepared with strontium hydroxyapatite and zoledronic acid: In vitro and pharmacodynamic evaluation

详细信息    查看全文

• 作者：Deepak Kumar Khajuria^a ; ^b ; ^{deepak_kumarkhajuria@yahoo.co.in} ; Ramakrishna Vasireddi^c ; Martin Trebbin^c ; David Karasik^a ; Rema Razdan^b
• 关键词：Strontium ; Hydroxyapatite ; Zoledronic acid ; Rat model ; Osteoporosis
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：698-708
• 全文大小：2191 K
• 卷排序：71

文摘

Nanoparticles of strontium-hydroxyapatite (SrHA) loaded with zoledronic acid (ZOL) were prepared. ZOL was used as a carrier to deliver SrHA nanoparticles to bones. SrHA/ZOL nanoparticle based drug formulation was tested in a rat model of postmenopausal osteoporosis. SrHA/ZOL therapy showed significant improvement in bone properties.