Regulation of zonation and homeostasis in the adrenal cortex

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• 作者：Emanuele Pignatti^a ; ^b ; ¹ ; Sining Leng^a ; ^c ; ¹ ; Diana L. Carlone^a ; ^b ; ^d ; David T. Breault^a ; ^b ; ^d ; ^{David.Breault@childrens.harvard.edu}
• 关键词：Adrenal cortex ; Zonation ; Transdifferentiation ; Stem cell ; Wnt/β-catenin ; ACTH
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：441
• 期：Complete
• 页码：146-155
• 全文大小：2523 K
• 卷排序：441

文摘

The adrenal cortex contains concentric zones without anatomical barriers. The different zones are distinguishable by morphology and steroidogenic activity. Wnt/β-catenin and ACTH/cAMP signaling pathways are essential for zonation. The capsule contains progenitor cells with limited activity in adult maintenance. Direct zG/zF conversion represents the major mechanism of adult tissue maintenance.