- 作者：Gang-Jun Zong ; Hai-Bin Jiang ; Yuan Bai ; Gang-Yong Wu ; Guang-Ming Ye ; Jing-Kai Chen ; Yong-Wen Qin ; Xian-xian Zhao
- 关键词：Aortic valve ; Percutaneous ; Ascending aorta ; Valved stent ; Very high-risk
- 刊名：Journal of Surgical Research
- 出版年：December, 2013
- 年：2013
- 卷：185
- 期：2
- 页码：940-944
- 全文大小：995 K
Purpose
We investigated the effects of percutaneous valved stent implantation in the ascending aorta as an alternative treatment for aortic regurgitation in a canine model.Materials and methods
A total of 16 healthy dogs weighing an average of 18.3 卤 2.1聽kg were used for the establishment of animal models of chronic aortic regurgitation by percutaneous aortic valve perforation and balloon dilation. At 2聽mo after successful model establishment, all experimental animals underwent valved stent implantation in the ascending aorta and then were followed up for 3聽mo.
Results
Experimental models of chronic aortic regurgitation were successfully established in 10 dogs. Surviving dogs underwent successful valved stent implantation in the ascending aorta and were subsequently followed up for 3聽mo. The level of instantaneous aortic regurgitation at 3-mo follow-up was significantly reduced compared with that before valved stent implantation (2.4 卤 0.9 versus 10.6聽卤聽2.1聽mL/s, P < 0.05). The left ventricular ejection fraction was significantly increased (53.8 卤 4.2% versus 37.8聽卤聽3.7%, P < 0.05), and the left ventricular end-diastolic volume was also significantly reduced (30.3 卤 2.2 versus 40.1聽卤聽3.6聽mL, P < 0.05). No paravalvular leak, stroke, atrioventricular block, or other complications occurred in dogs undergoing valved stent implantation.
Conclusions
Percutaneous valved stent implantation in the ascending aorta is feasible, effective, and safe as an alternative treatment for very high-risk aortic regurgitation in a canine model.