Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway
详细信息 查看全文
- 作者：Shiyang Li1 ; 2 ; 3 ; 8 ; Jennifer J. Heller1 ; 2 ; 8 ; John W. Bostick1 ; 2 ; 4 ; Aileen Lee1 ; 2 ; Hilde Schjerven5 ; Philippe Kastner6 ; Susan Chan6 ; Zongming E. Chen7 ; Liang Zhou1 ; 2 ; 3 ; liangzhou497@ufl.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：19 July 2016
- 年：2016
- 卷：45
- 期：1
- 页码：185-197
- 全文大小：3568 K
文摘
- listitem" id="list_ulist0010">
- •
Ikaros suppresses postnatal ILC3 development in a cell-intrinsic manner
- •
Suppression of ILC3 development depends on the zinc finger 4 domain of Ikaros
- •
Ikaros interacts with Ahr and inhibits Ahr transcriptional activity
- •
Ikaros regulates gut immunity in a cell-type-specific manner