Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus
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- 作者：Zongyang Mou1 ; 2 ; Thomas M. Hyde3 ; 4 ; 5 ; Barbara K. Lipska6 ; Keri Martinowich3 ; 4 ; Peter Wei1 ; 7 ; Chiew-Jen Ong1 ; 7 ; Lindsay A. Hunter1 ; 7 ; Gladys I. Palaguachi1 ; 7 ; Eva Morgun1 ; 2 ; Rujia Teng1 ; Chen Lai1 ; 7 ; Tania A. Condarco2 ; Andrew P. Demidowich2 ; Amanda J. Krause2 ; Leslie J. Marshall8 ; Karin Haack9 ; V. Saroja Voruganti9 ; 10 ; Shelley A. Cole9 ; Nancy F. Butte11 ; Anthony G. Comuzzie9 ; Michael A. Nalls12 ; Alan B. Zonderman13 ; Andrew B. Singleton12 ; Michele K. Evans14 ; Bronwen Martin15 ; Stuart Maudsley16 ; 17 ; 18 ; Jack W. Tsao2 ; 7 ; 19 ; Joel E. Kleinman3 ; 4 ; 5 ; Jack A. Yanovski2 ; Joan C. Han1 ; 2 ; 20 ; 21 ; jhan14@uthsc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mou et al. show that brain-derived neurotrophic factor (BDNF) rs12291063 minor C allele disrupts binding and transactivation by the transcriptional regulator ; heterogeneous nuclear ribonucleoprotein D0B ; and it is associated with lower ventromedial hypothalamic BDNF expression and obesity. BDNF augmentation may be specifically beneficial for treating obesity in individuals with the CC genotype
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：10 November 2015
- 年：2015
- 卷：13
- 期：6
- 页码：1073-1080
- 全文大小：1859 K
文摘
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BDNF rs12291063 minor C allele is associated with obesity in children and adults
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Minor C allele disrupts binding and transactivation by hnRNPD0B
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Minor C allele is associated with lower human hypothalamic BDNF expression
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BDNF augmentation could be a CC genotype-specific targeted therapy for obesity