Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer
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- 作者：Weimin Wang1 ; 2 ; Ilona Kryczek2 ; Lubomí ; r Dostá ; l3 ; Heng Lin2 ; Lijun Tan1 ; Lili Zhao4 ; Fujia Lu2 ; Shuang Wei2 ; Tomasz Maj2 ; Dongjun Peng2 ; Gong He1 ; Linda Vatan2 ; Wojciech Szeliga2 ; Rork Kuick4 ; Jan Kotarski5 ; Rafał Tarkowski5 ; Yali Dou6 ; Ramandeep Rattan7 ; Adnan Munkarah7 ; J. Rebecca Liu1 ; 8 ; 10 ; rliu@med.umich.edu" class="auth_mail" title="E-mail the corresponding author ; Weiping Zou2 ; 8 ; 9 ; 10 ; wzou@med.umich.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：19 May 2016
- 年：2016
- 卷：165
- 期：5
- 页码：1092-1105
- 全文大小：4403 K
文摘
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Fibroblasts diminish platinum content in cancer cells, resulting in drug resistance
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GSH and cysteine released by fibroblasts contribute to platinum resistance
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T cells alter fibroblast GSH and cystine metabolism and abolish the resistance
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Fibroblasts and CD8+ T cells associate with patient chemotherapy response