A Comprehensive Analysis of the Dynamic Response to Aphidicolin-Mediated Replication Stress Uncovers Targets for ATM and ATMIN
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- 作者：Abdelghani Mazouzi1 ; Alexey Stukalov1 ; 2 ; André ; C. Mü ; ller1 ; Doris Chen1 ; Marc Wiedner1 ; Jana Prochazkova1 ; Shih-Chieh Chiang3 ; Michael Schuster1 ; Florian P. Breitwieser1 ; 4 ; Andreas Pichlmair2 ; Sherif F. El-Khamisy3 ; Christoph Bock1 ; Robert Kralovics1 ; Jacques Colinge1 ; 5 ; Keiryn L. Bennett1 ; Joanna I. Loizou1 ; jloizou@cemm.oeaw.ac.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：replication stress ; phosphoproteomics ; gene regulation ; ATM ; ATMIN ; γH2AX ; CRMP2
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：26 April 2016
- 年：2016
- 卷：15
- 期：4
- 页码：893-908
- 全文大小：6336 K
文摘
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Replication stress triggers widespread changes in phosphorylation and expression
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ATM-ATMIN regulate phosphorylation events and expression upon replication stress
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ATMIN modulates the phosphorylation of H2AX and CRMP2 following replication stress
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Replication-stress-induced phosphorylation of CRMP2 regulates genome stability