Totally S-protected hyaluronic acid: Evaluation of stability and mucoadhesive properties as liquid dosage form
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- 作者：Irene Pereira de Sousa ; Wongsakorn Suchaoin ; Ožbej Zupančič ; Christina Leichner ; Andreas Bernkop-Schnü ; rch ; Andreas.Bernkop@uibk.ac.at" class="auth_mail" title="E-mail the corresponding author ; a.bernkop@thiomatrix.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mucoadhesion ; Preactivation ; Thiolation ; Biological barrier ; Liquid dosage form
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：5 November 2016
- 年：2016
- 卷：152
- 期：Complete
- 页码：632-638
- 全文大小：964 K
文摘
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Totally S-protected hyaluronic acid showing prolonged stability at physiological pH and under oxidative conditions could be successfully synthesized.
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Totally S-protected hyaluronic acid showed a 52-fold higher viscosity when incubated with mucus compared to native hyaluronic acid.
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The mucoadhesive properties of totally S-protected hyaluronic acid were confirmed by tensile test both in intestinal mucosa and palpebral conjunctiva.
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Totally S-protected hyaluronic acid appears to be a promising excipient for the formulation of mucoadhesive liquid dosage forms.