A crosstalk between TGF-β/Smad3 and Wnt/β-catenin pathways promotes vascular smooth muscle cell proliferation
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- 作者：Daniel M. DiRenzoa ; 1 ; Mirnal A. Chaudharya ; 1 ; Xudong Shia ; Sarah R. Francoa ; Joshua Zenta ; Katie Wanga ; Lian-Wang Guoa ; guo@surgery.wisc.edu" class="auth_mail" title="E-mail the corresponding author ; K. Craig Kenta ; b ; kent@surgery.wisc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：TGF-β/Smad3 ; Wnt/β-catenin ; Vascular smooth muscle cells ; Proliferation
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：28
- 期：5
- 页码：498-505
- 全文大小：1105 K
文摘
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A crosstalk between TGFβ/Smad3 and Wnt/β-Catenin pathways in vascular smooth muscle cells has not been previously reported.
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The transition of smooth muscle cells from a normal to a proliferative phenotype is key to occlusive vascular diseases.
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We find elevated TGFβ/Smad3 up-regulate several Wnts which stabilize β-Catenin promoting smooth muscle cell proliferation.