Maternal exposure to fine particulate air pollution induces epithelial-to-mesenchymal transition resulting in postnatal pulmonary dysfunction mediated by transforming growth factor-β/Smad3 signaling

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• 作者：Wenting Tang^a ; ^b ; Lili Du^a ; Wen Sun^a ; Zhiqiang Yu^c ; Fang He^a ; Jingsi Chen^a ; Xiaomei Li^a ; Xiuying Li^a ; Lin Yu^a ; Dunjin Chen^a ; ^{gzdrchen@gzhmu.edu.cn}
• 关键词：PM2.5 ; Offspring ; EMT ; Pulmonary dysfunction
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：267
• 期：Complete
• 页码：11-20
• 全文大小：3476 K
• 卷排序：267

文摘

Maternal exposure to PM2.5 induces fetal pulmonary dysfunction. EMT may plays a role in maternally PM2.5-exposed fetal pulmonary pathology. EMT, ROS and the TGF-β/Smad3 pathway are interrelated and interact on each other. EMT might also participate in the healing process following lung injury.