Lizard contains only one IFNL locus, while turtle and crocodile have two loci.
Homologues of human IFNL4 gene may exist widely in mammal lineage.
Amniote IFNL genes can be grouped into two clades in phylogenetic tree.
Lizard IFNL promoter report plasmid can be activated by lizard IRF3.
Lizard IFNL and its receptors IFNLR1 and IL10RB are functional in expression of ISGs.