Evolution of IFN-λ in tetrapod vertebrates and its functional characterization in green anole lizard (Anolis carolinensis)
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- 作者：Shan Nan Chena ; b ; Xiao Wen Zhanga ; b ; Li Lia ; b ; Bai Ye Ruana ; b ; Bei Huangc ; Wen Shu Huangc ; Peng Fei Zouc ; Jian Ping Fua ; Li Juan Zhaoa ; Nan Lia ; Pin Niea ; pinnie@ihb.ac.cn" class="auth_mail" title="E-mail the corresponding author ; pniefish@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：IFN-λ ; IFNL ; IFNLR1 ; IL10RB ; Evolution ; Lizard
- 刊名：Developmental & Comparative Immunology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：61
- 期：Complete
- 页码：208-224
- 全文大小：7519 K
文摘
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Lizard contains only one IFNL locus, while turtle and crocodile have two loci.
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Homologues of human IFNL4 gene may exist widely in mammal lineage.
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Amniote IFNL genes can be grouped into two clades in phylogenetic tree.
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Lizard IFNL promoter report plasmid can be activated by lizard IRF3.
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Lizard IFNL and its receptors IFNLR1 and IL10RB are functional in expression of ISGs.