Compartmentalized localization of 11β-HSD 1 and 2 at the feto-maternal interface in the first trimester of human pregnancy
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- 作者：Qianlan Yanga ; b ; Wangsheng Wanga ; c ; Chao Liua ; c ; Yu Wangb ; renjiwangyu@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Kang Suna ; c ; sungangrenji@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Decidua ; Trophoblasts ; 11β-HSD1 ; 11β-HSD2 ; Glucocorticoids ; Pregnancy
- 刊名：Placenta
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：46
- 期：Complete
- 页码：63-71
- 全文大小：2449 K
文摘
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Optimal cortisol concentration at the feto-maternal interface is crucial for early gestation.
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Cortisol regeneration by 11β-HSD1 was mainly on the maternal side.
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Cortisol inactivation by 11β-HSD2 was confined to the lining surfaces of both sides.
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Cortisol upregulated 11β-HSD1 and 2 on the maternal and fetal sides respectively.