Identification of miRNomes in human stomach and gastric carcinoma reveals miR-133b/a-3p as therapeutic target for gastric cancer
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- 作者：Yanfang Liua ; b ; 1 ; Xin Zhangc ; 1 ; Yujing Zhangd ; 1 ; Zunqi Huc ; Dejun Yangc ; Changming Wangc ; Meng Guoe ; Guo918meng@163.com" class="auth_mail" title="E-mail the corresponding author ; Qingping Caic ; caiqp1969@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：microRNA ; Gastric cancer ; miRNomes ; Apoptosis ; Therapy
- 刊名：Cancer Letters
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：369
- 期：1
- 页码：58-66
- 全文大小：3666 K
文摘
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Heatmap analysis of the miRNomes was performed across TCGA datasets.
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miR-133 is downregulated in gastric cancer.
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Downregulation of miR-133 is mediated by histone modification.
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miR-133 promotes gastric cancer cell apoptosis by targeting Mcl-1 and Bcl-xL.
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Anti-tumor effect of miR-133 was verified in xenograft mice.