MiR-133b ameliorates axon degeneration induced by MPP+ via targeting RhoA
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- 作者：M. Niu&dagger ; ; R. Xu&dagger ; ; J. Wang ; B. Hou ; A. Xie ; xieanmu@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DMEM ; Dulbecco&rsquo ; s modified Eagle&rsquo ; s medium ; DNs ; dopaminergic neurons ; GFP ; green fluorescent protein ; LV-miR-133b ; lentivirus overexpressing miR-133b ; LV-miR-NC ; negative control lentiviral vectors ; MiR ; microRNA ; MPP+ ; 1-methyl-4-phenyl-pyridinium ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyl tetrazolium bromide ; p-Akt ; phosphorylated Akt ; PD ; Parkinson&rsquo ; s disease ; RMT ; rostral mesencephalic tegmentum ; ROCK ; Rho-associated kinase ; RT-PCR ; real-time PCR ; Wlds ; Wallerian degener
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：14 June 2016
- 年：2016
- 卷：325
- 期：Complete
- 页码：39-49
- 全文大小：1164 K
文摘
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MiR-133b ameliorates axon degeneration induced by MPP+ via targeting RhoA.
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MiR-133b inhibits MPP+ induced α-synuclein up-regulation.
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Novel roles for miR-133b in pathogenesis of PD are proposed.