MiR-145, miR-133a and miR-133b inhibit proliferation, migration, invasion and cell cycle progression via targeting transcription factor Sp1 in gastric cancer

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• 作者：Tianzhu Qiu¹ ; Xin Zhou¹ ; Jian Wang ; Yiping Du ; Jun Xu ; Zebo Huang ; Wei Zhu ; Yongqian Shu ; Ping Liu ; ^{liu-ping@csco.org.cn" class="auth_mail}
• 关键词：Gastric cancer ; miR-145 ; miR-133a ; miR-133b ; Proliferation ; Migration ; Invasion ; Cell cycle progression ; Sp1
• 刊名：FEBS Letters
• 出版年：2 April, 2014
• 年：2014
• 卷：588
• 期：7
• 页码：1168-1177
• 全文大小：3058 K

文摘

MicroRNAs have recently emerged as key regulators of gastric cancers. Here we found that miR-145, miR-133a and miR-133b were down-regulated in gastric cancer tissues and cell lines. Overexpression of miR-145, miR-133a and miR-133b induced G1 cell cycle arrest and inhibited cell proliferation, migration and invasion in vitro. MiR-145, miR-133a and miR-133b targeted the transcription factor SP1, knockdown of which reduced the expression of MMP-9 and Cyclin D1 that were involved in cell growth and invasion. Thus, our findings demonstrated for the first time that miR-145, miR-133a and miR-133b suppressed the proliferation, migration, invasion and cell cycle progression of gastric cancer cells through decreasing expression of Sp1 and its downstream proteins.