MicroRNA-133b inhibits hepatocellular carcinoma cell progression by targeting Sirt1
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- 作者：Zhijie Tiana ; Hequn Jiangb ; Ying Liua ; Yong Huanga ; Xin Xiongd ; Hongwei Wub ; hongweiwu2118@sina.com" class="auth_mail" title="E-mail the corresponding author ; Xiaozhen Daia ; c ; e ; xiaozhendai2012@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：MiR-133b ; Sirt1 ; Hepatocellular carcinoma ; Proliferation ; Apoptosis
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：343
- 期：2
- 页码：135-147
- 全文大小：6928 K
文摘
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Sirt1 is a direct target of miR-133b in HCC.
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miR-133b over-expression suppresses HCC progression in vitro and in vivo.
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Sirt1 restoration reverses the effect of miR-133b over-expression on HCC cells.
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GPC3 down-regulation reverses the effect of Sirt1 up-regulation on HCC cells.
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Sirt1 activates Wnt β-catenin signaling by GPC3 in vitro.