Drosophila Cancer Models Identify Functional Differences between Ret Fusions
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- 作者：Sarah Levinson1 ; Ross L. Cagan1 ; 2 ; ross.cagan@mssm.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：13 September 2016
- 年：2016
- 卷：16
- 期：11
- 页码：3052-3061
- 全文大小：2507 K
文摘
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Drosophila RET fusion cancer models have multiple transformation phenotypes
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Similar to patients, NCOA4-RET presents with more severe phenotypes than CCDC6-RET
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CCDC6-RET and NCOA4-RET activate distinct pathways and have different drug sensitivity
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A drug treatment, sorafenib plus AZD1775 (MK-1775), was effective for NCOA4-RET animals