Development of a human live attenuated West Nile infectious DNA vaccine: Identification of a minimal mutation set conferring the attenuation level acceptable for a human vaccine

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• 作者：Vladimir Yamshchikov ; ^{yaximik@gmail.com} ; Marina Manuvakhova ; Efrain Rodriguez ; Charles Hé ; bert
• 关键词：WNV ; Vaccine ; iDNA ; JEV ; SA14-14-2 ; W956 ; W1806 ; Attenuation ; Envelope ; Mice
• 刊名：Virology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：500
• 期：Complete
• 页码：122-129
• 全文大小：691 K
• 卷排序：500

文摘

Effect of mutations in E on properties of WN1806 is determined. A subset of attenuating mutations suitable for a human vaccine is defined. Mechanism of attenuation is proposed and illustrated. Underlying mechanisms of neurovirulence reversion are suggested.