Targeted delivery of small interfering RNA to colon cancer cells using chitosan and PEGylated chitosan nanoparticles
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- 作者：Walter E. Rudzinskia ; WR01@txstate.edu" class="auth_mail" title="E-mail the corresponding author ; Adriana Palaciosa ; 1 ; Adriana.S.Palacios@ttuhsc.edu" class="auth_mail" title="E-mail the corresponding author ; Abuzar Ahmeda ; 2 ; abuzarahmed01@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Michelle A. Laneb ; ML48@txstate.edu" class="auth_mail" title="E-mail the corresponding author ; Tejraj M. Aminabhavic ; aminabhavit@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chitosan (PubChem CID 71853) ; Sodium triphosphate pentabasic (PubChem CID 24455)
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 August 2016
- 年：2016
- 卷：147
- 期：Complete
- 页码：323-332
- 全文大小：2560 K
文摘
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Chitosan-based nanoparticles containing siRNA were of the correct size to enter cells.
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Nanoparticles containing fluorescent siRNA entered human colon cancer cells.
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Nanoparticles with siRNA targeting β-catenin decreased this protein in cancer cells.