Differential pro-apoptotic effect of allicin in oestrogen receptor-positive or -negative human breast cancer cells
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- 作者：Kyung-Ho Kima ; 1 ; Seong-Jun Chob ; 1 ; Byung-Oh Kimc ; Suhkneung Pyoa ; snpyo@skku.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Allicin (PubChem CID ; 65036) ; Penicillin (PubChem CID ; 5904) ; Streptomycin (PubChem CID ; 19649) ; HEPES (PubChem CID ; 23831) ; CM-H2DCFDA (PubChem CID ; 23847176) ; JC-1 (PubChem CID ; 5492929) ; Cytochrome c (PubChem CID ; 16057918) ; MTT (PubChem CID ; 64965) ; Ethanol (PubChem CID ; 702) ; Propidium iodide (PubChem CID ; 104981) ; FITC (PubChem CID ; 18730) ; Formaldehyde (PubChem CID ; 62705) ; MgCl2 (PubChem CID ; 5360315) ; KCl (PubChem CID ; 4873) ; DTT (PubChem CID ; 446094) ; PMSF (PubChem CID ; 4784) ; SDS (Pub
- 刊名：Journal of Functional Foods
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：25
- 期：Complete
- 页码：341-353
- 全文大小：2050 K
文摘
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Allicin induced apoptosis in ERα+ and ERα− human breast cancer cells.
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Allicin induced ROS-mediated apoptosis in MDA-MB-231 cells unlike in MCF7 cells.
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Allicin induced both caspase-dependent and -independent apoptotic pathways.
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ERα has a protective role during allicin-induced apoptosis in breast cancer cells.