Bioconversion of 6-(N-methyl-N-phenyl)aminomethyl androstane steroids by Nocardioides simplex

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• 作者：Galina Sukhodolskaya^a ; ^{sukhodolskaya@rambler.ru} ; Victoria Fokina^a ; ^{vvfokina@rambler.ru} ; Andrei Shutov^a ; ^{w___w@rambler.ru} ; Vera Nikolayeva^a ; ^{nikolae_vera@rambler.ru} ; Tatiana Savinova^b ; ^{tatiana_savinova@rambler.ru} ; Yuri Grishin^b ; ^{grishin@nmr.chem.msu.ru} ; Alexey Kazantsev^b ; ^{mak@org.chem.msu.ru} ; Nikolay Lukashev^b ; ^{nvlukashev@gmail.com} ; Marina Donova^a ; ^{donova-marina@rambler.ru}
• 关键词：Androst-4-ene-3 ; 17-dione (PubChem CID ; 6128) ; Androsta-1 ; 4-diene-3 ; 17-dione (PubChem CID ; 13472) ; Testosterone (PubChem CID ; 6013) ; Dehydrotestosterone (PubChem CID ; 6422)
• 刊名：Steroids
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：118
• 期：Complete
• 页码：9-16
• 全文大小：503 K
• 卷排序：118

文摘

Nocardioides simplex converts 6-(N-methyl-N-phenyl)aminomethyl androstanes. Only β-stereoisomers undergo 1(2)-dehydrogenation with N. simplex cells. (N-methyl-N-phenyl)aminomethyl substitution at C6 prevents biodegradation of steroid core.