A novel systems pharmacology platform to dissect action mechanisms of traditional Chinese medicines for bovine viral diarrhea disease

详细信息    查看全文

• 作者：Chunli Zheng^a ; ¹ ; Tianli Pei^a ; ^b ; ¹ ; Chao Huang^a ; Xuetong Chen^a ; Yaofei Bai^a ; Jun Xue^a ; ^b ; Ziyin Wu^a ; Jiexin Mu^b ; Yan Li^c ; Yonghua Wang^b ; ^{yh_wang@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Baicalin (PubChem CID ; 64982) ; Crocetin (PubChem CID ; 5281232) ; Chrysin (PubChem CID ; 5281607) ; Epicatechin (PubChem CID ; 72276) ; Magnoflorine (PubChem CID ; 73337) ; Isoimperatorin (PubChem CID ; 68081)
• 刊名：European Journal of Pharmaceutical Sciences
• 出版年：2016
• 出版时间：30 October 2016
• 年：2016
• 卷：94
• 期：Complete
• 页码：33-45
• 全文大小：2253 K

文摘

Due to the large direct and indirect productivity losses in the livestock industry caused by bovine viral diarrhea (BVD) and the lack of effective pharmacological therapies, developing an efficient treatment is extremely urgent. Traditional Chinese medicines (TCMs) that simultaneously address multiple targets have been proven to be effective therapies for BVD. However, the potential molecular action mechanisms of TCMs have not yet been systematically explored. In this work, take the example of a herbal remedy Huangqin Zhizi (HQZZ) for BVD treatment in China, a systems pharmacology approach combining with the pharmacokinetics and pharmacodynamics evaluation was developed to screen out the active ingredients, predict the targets and analyze the networks and pathways. Results show that 212 active compounds were identified. Utilizing these lead compounds as probes, we predicted 122 BVD related-targets. And in vitro experiments were conducted to evaluate the reliability of some vital active compounds and targets. Network and pathway analysis displayed that HQZZ was effective in the treatment of BVD by inhibiting inflammation, enhancing immune responses in hosts toward virus infection. In summary, the analysis of the complete profile of the pharmacological activities, as well as the elucidation of targets, networks and pathways can further elucidate the underlying anti-inflammatory, antiviral and immune regulation mechanisms of HQZZ against BVD.